A Global Optimization Algorithm for Sparse Mixed Membership Matrix Factorization

Abstract

Mixed membership factorization is a popular approach for analyzing data sets that have within-sample heterogeneity. In recent years, several algorithms have been developed for mixed membership matrix factorization, but they only guarantee estimates from a local optimum. Here, we derive a global optimization algorithm that provides a guaranteed e-global optimum for a sparse mixed membership matrix factorization problem. We test the algorithm on simulated data and a small real gene expression dataset and find the algorithm always bounds the global optimum across random initializations and explores multiple modes efficiently.

Publication
Contemporary Biostatistics with Biopharmaceutical Applications
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